Selected Publications

Leonard J, Kepplinger D, Hu C-H, Veneziano R, Hoemann CD. Comparative analysis of Lox-1 and CD36 expression in human platelets and on circulating microparticles during ARDS-induced coagulopathy.  Thrombosis Research, in press  https://doi.org/10.1016/j.thromres.2024.109202

Leonard J, Kepplinger D, Espina V, Gillevet P, Ke Y, Birukov  Hoemann CD.   Whole blood coagulation induces clot neutrophils to adopt a myeloid-derived suppressor cell signature and shed sLox-1. J. Hemostasis Thrombosis, 2024: 22(4):1031-45. doi: 10.1016/j.jtha.2023.12.014.  https://pubmed.ncbi.nlm.nih.gov/38135253/

Chandrasekaran R, Mathieu C, Sheth R, Cheng AP, Fong D, McCormack R, El Gabalawy H, Alishetty S, Paige M, Hoemann CD. UDP-glucose dehydrogenase (UGDH) activity is suppressed by peroxide and promoted by PDGF: evidence of a redox control mechanism. PLoS One. 2022;17(9):e0274420  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0274420

Hoemann, C.D. Rodriguez Gonzáles J, Guzmán-Morales J, Chen G, Jalili Dil E, Favis B. Chitosan coatings with distinct innate immune bioactivities differentially stimulate angiogenesis, osteogenesis and chondrogenesis in poly-caprolactone scaffolds with controlled interconnecting pore size. Bioactive Materials, 2022;10:430-442.    https://www.sciencedirect.com/science/article/pii/S2452199X21004291

Verhoef, P.A., Kannan, S., Sturgill, J.L., Tucker, E.W., Morris, P.E., Miller, A.C., Sexton, T.R., Koyner, J.L., Hejal, R., Brakenridge, S.C., Moldawer, L.L., Hotchkiss, R.S., Blood, T.M., Mazer, M.B., Bolesta, S., Alexander, S.A., Armaignac, D.L., Shein, S.L., Jones, C., Hoemann, C.D., Doctor, A., Friess, S.H., Parker, R.I., Rotta, A.T., Remy, K.E., Medicine,for the B. and T.S.C. of the R.S. for the S. of C.C., 2021. Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research. Critical Care Explorations 3, e0374. https://doi.org/10.1097/CCE.0000000000000374

Hoemann CD, Guzmán-Morales J, Picard G, Chen G, Veilleux, D, Chevrier A, Sim S, Garon M, Quenneville E, Lafantaisie-Favreau C-H, Buschmann MD, Hurtig MB. Guided bone marrow stimulation for articular cartilage repair through a freeze-dried chitosan microparticle approach. Materialia, 2020;9. Article No. UNSP 100609. DOI: 10.1016/j.mtla.2020.100609 https://www.sciencedirect.com/science/article/abs/pii/S2589152920300260

Mantripragada, VP, Gao W, Piuzzi NS, Hoemann CD, Muschler GF, Midura RJ. Comparative Assessment of Primary Osteoarthritis Progression Using Conventional Histopathology, Polarized Light Microscopy, and Immunohistochemistry. Cartilage. 2020; Article No. 1947603520938455; DOI: 10.1177/1947603520938455.   https://journals.sagepub.com/doi/10.1177/1947603520938455

Dwivedi G, Chevrier, A, Alameh M, Hoemann CD, Buschmann MD Injectable freeze-dried chitosan-platelet-rich-plasma implants improve marrow stimulated cartilage repair in a chronic-defect rabbit model. Journal of Tissue Engineering and Regenerative Medicine, 2019;4:599-611. https://onlinelibrary.wiley.com/doi/abs/10.1002/term.2814

Contreras-Garcia A, D’Elia N, Desgagné M, Lafantaisie-Favreau CH, Rivard, GE, Wertheimer MR, Messina P, Hoemann CD. Synthetic anionic surfaces can replace microparticles in stimulating burst coagulation of blood plasma. Colloids and Surfaces B, 2019;175:596-605. https://www.sciencedirect.com/science/article/abs/pii/S0927776518308488

Dwivedi G, Chevrier, A, Alameh M, Hoemann CD, Buschmann MD. Quality of cartilage repair from marrow stimulation correlates with cell number, clonogenic, chondrogenic and matrix production potential of underlying bone marrow stromal cells Cartilage, Dec 20, 2018 e-pub ahead of print https://doi.org/10.1177/1947603518812555

Hoemann CD, Guimond, M.  Immunological Responses in Orthopedics and Transplantation. Encyclopedia of Biomedical Engineering. Ed D. Mantovani. Elsevier’s Biomedical Sciences Reference Module. 2018

Hoemann CD, Marchand C, Rivard GE, El-Gabalawy H, Poubelle PE. Effect of chitosan and coagulation factors on the wound repair phenotype of bioengineered blood clots. International Journal of Biological Macromolecules, 2017;104(Pt B):1916-1924. Invited paper, special issue on Chitin and Chitosan. https://www.sciencedirect.com/science/article/abs/pii/S0141813017301769?via%3Dihub

Fong D, Hoemann CD. Chitosan immunomodulatory properties: Perspectives on the impact of structural properties and dosage Future Science OA. Invited Expert Opinion paper. 2017;14;4(1):FSO225.  https://www.future-science.com/doi/10.4155/fsoa-2017-0064

Hoemann CD, Fong D. Chapter 3: Immunological Responses to Chitosan for Biomedical Applications. In: Chitosan Based Biomaterials Volume 1: Fundamentals. Ed. JA Jennings, JD Bumgardner. (Woodhead Publishing Series in Biomaterials, Elsevier, United Kingdom) 2017

Li X, Ghavidel Mehr N, Favis B, De Crescenzo G, Yakandawala N, Hoemann CD. Cationic osteogenic peptide P15-CSP coatings promote 3-D osteogenesis in poly(epsilon-caprolactone) scaffolds of distinct pore size. J Biomedical Mater Res Pt A, 2017;105(8):2171-2181.

Fong D, Grégoire-Gélinas P, Cheng AP, Mezheritsky T, Lavertu M, Sato S and Hoemann CD. Structurally distinct chitosans induce lysosomal rupture to promote either a type 1 IFN response or activate the inflammasome in macrophages. Biomaterials, 2017:129:127-38  https://www.sciencedirect.com/science/article/pii/S0142961217301667?via%3Dihub

Fong D, Duceppe N, Hoemann CD. Mesenchymal stem cell detachment with trace trypsin is superior to EDTA for in vitro chemotaxis and adhesion assays. BBRC, 2017;484(3):656-661

Bell A, Hurtig MB, Quenneville E, Rivard GE, Hoemann CD. Effect of a rapidly degrading presolidified 10 kDa chitosan/blood implant and subchondral marrow stimulation (SMS) surgical approach on cartilage resurfacing in a sheep model. Cartilage 2017; 8(4):417-431

Hoemann CD, Tran-Khanh N, Chevrier A,  Chen G, Lascau-Coman V, Mathieu C, Yaroshinsky A, McCormack R, Stanish WD, Buschmann MD. Chondroinduction is the main cartilage repair response to microfracture and microfracture with BST-CarGel: Results as shown by ICRS-II histological scoring and a novel zonal collagen type (ZCT) scoring method of human clinical biopsy specimens. Am J Sports Med. 2015;43(10):2469-80.

Ghavidel Mehr N, Li X, Chen, G, Favis B, Hoemann CD Pore size and LbL chitosan coating influence mesenchymal stem cell in vitro fibrosis and biomineralization in 3-D porous poly(epsilon-caprolactone) scaffolds J Biomedical Materials Res Pt A, 2015;103(7):2449-2459.

Fong D, Arignaello MB, Girard-Lauzière J, Hoemann CD. Biodegradable chitosan microparticles induce delayed STAT-1 activation and lead to distinct cytokine responses in differentially polarized human macrophages in vitro. Acta Biomaterialia, 2015;12:183-194.

Guzman-Morales J, Lafantaisie-Favreau C-H, Chen G, Hoemann CD. Subchondral chitosan/blood implant-guided bone plate resorption and woven bone repair is coupled to hyaline cartilage regeneration from microdrill holes in aged rabbit knees Osteoarthritis & Cartilage, 2014;22(2):323-33.

Hoemann CD, Gosselin Y, Chen H, Sun J, Hurtig MB, Carli A, Stanish WD. Characterization of initial microfracture defects in human condyles. J. Knee Surgery, 2013;26(5):347-55.

Mathieu C, Chevrier A, Lascau-Coman V, Rivard G-E, Hoemann CD. Stereological analysis of subchondral angiogenesis induced by chitosan and coagulation factors in microdrilled articular cartilage defects. 2013 Osteoarthritis & Cartilage, 21(6):849-59.

Bell A, Lascau-Coman V, Sun J, Lowerison M, Hurtig MB, Hoemann CD. Bone-induced chondroinduction in sheep Jamshidi biopsy defects with and without treatment by subchondral chitosan-blood implant: 1 day, 3 week, and 3 month repair. Cartilage 2013;4(2):131-143

Hoemann CD, Guzman-Morales J, Tran-Khanh N, Lavallée G, Jolicoeur M, Lavertu M. Chitosan rate of uptake in HEK293 cells is influenced by soluble versus microparticle state and enhanced by serum-induced cell metabolism. Molecules 2013;18(1):1015-35. Special Issue on chitin and chitosan.

Lafantaisie-Favreau C-H, Guzman-Morales J, Sun J, Harris A, Smith TD, Carli A, Henderson J, Stanish WD, Hoemann CD. Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil chemotaxis, bone resorption and repair, enhanced repair tissue integration, and delayed matrix deposition. BMC Musculoskeletal Disorders, 2013;14:27+.

Hoemann CD, Lafantaisie-Favreau C-H, Lascau-Coman V, Chen G, Guzman-Morales J. The cartilage-bone interface.  J. Knee Surgery, 2012:25(02): 085-098

Guzmán-Morales J, Ariganello M, Hammond I, Thibault M, Jolicoeur M, Hoemann CD. Biodegradable chitosan particles induce chemokine release and negligible arginase-1 activity compared to IL-4 in murine bone marrow-derived macrophages. BBRC, 2011;405(4):538-544

Marchand C, Chen H, Buschmann MD, Hoemann CD. Standardized 3D volumes of interest with adapted surfaces for more precise subchondral bone analyses by micro-CT Tissue Engineering - Part C, 2011;17(4):475-484.

Chen G, Sun J, Lascau-Coman V,  Chevrier A, Marchand C, Hoemann CD. Acute osteoclast activity following subchondral drilling is promoted by chitosan and associated with improved cartilage repair tissue integration. Cartilage, 2011;2:173-185

Hoemann CD, Chen GP, Marchand C, Sun J, Tran-Khanh N, Chevrier A, Thibault M, Fernandes MGJ, Poubelle PE, Shive MS, Centola M, and El-Gabalawy H. Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages. Am J Sports Med. 2010;38(9):1845-56

Marchand C, Bachand J, Périnet J, Baraghis E, Lamarre M, Rivard GE, DeCrescenzo G, Hoemann CD.  C3, C5 and factor B bind to chitosan without complement activation.  J Biomedical Mater Res Part A. 2010;93A(4):1429-1441   

Guzmán-Morales J, El-Gabalawy H, Pham, HM, Tran-Khanh N, McKee MD, Centola M, Hoemann, CD. Effect of chitosan particles and dexamethasone on human bone marrow stromal cell osteogenesis and angiogenic factor secretion. Bone 2009;45:617-626

Hoemann CD, El-Gabalawy H, McKee MD. In vitro osteogenesis assays: Influence of the primary cell source on alkaline phosphatase activity and mineralization. Pathologie Biologie, 2009;57:318–323.

Simard P, Galarneau H, Marois S, Rusu D, Hoemann CD, Poubelle PE, El-Gabalawy H and Fernandes MJG. Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair. Arthritis Res Therapy, 2009;11(3):R74

Marchand C, Rivard GE, Sun J, Hoemann CD.  Mechanisms of solidification of chitosan-glycerol phosphate/blood implant for articular cartilage repair.  Osteoarthritis & Cartilage 2009; 17(7): 950-957

Ma O, Lavertu M,  Sun J, Nguyen S, Buschmann MD, Winnik F, and Hoemann CD.   Precise Derivatization of Structurally Distinct Chitosans with Rhodamine B Isothiocyanate. Carbohydrate Polymers, 2008;72(4):616-624.